Preheat oven to 350°F/175°C. Line three 8-inch round pans with parchment rounds and grease with non-stick cooking spray or homemade cake release. Mix 3 cups flour, 3 cups sugar, 2 1/2 tsp baking powder, 1 Tbsp cinnamon, 1 1/2 tsp ginger, 1 tsp fine salt, and 3/4 tsp nutmeg together in a stand mixer with a paddle attachment or hand mixer until fully combined.
Gradually mix 1 cup of room-temperature unsalted butter into the dry ingredients at a low speed. Continue to mix until no large chunks of butter remain, and the mixture looks like moist sand.
Mix in 2/3 cup pumpkin puree (no need to blot or pat it with a paper towel in this recipe) and 1/2 cup egg whites on low until just incorporated. Scrape the sides and bottom of the bowl as needed with a rubber spatula.
Then mix in 1 1/2 cups buttermilk, 2 Tbsp of vegetable oil, 1 tsp of vanilla extract, and a small squirt of orange gel food coloring (optional) on low speed until fully incorporated. Scrape down the sides of the bowl with a rubber spatula one more time, then beat on medium speed for about 30 seconds to make sure everything is properly mixed together. This also helps lighten the texture of the cake layers.
Divide the batter evenly between the cake pans (about 630g per pan if you make 3 layers). Bake for 33-35 minutes, or until a toothpick comes out with a few moist crumbs. Rotate the pans halfway through to help them bake evenly.
Let the pans cool for 10 minutes, then run a small offset spatula around the edges. Place the pans in the freezer for 30 minutes to speed up the cooling process. Once the layers are fully cooled, carefully flip the pans and remove the layers.
These cake layers bake up pretty flat, but I like to use a serrated knife to level the tops and remove any caramelization around the sides of the layers. This step is optional but makes the cake a lot easier to frost. You can also trim the layers, then wrap and freeze them if you're making them in advance.
If you make these cake layers in advance and freeze them, let them thaw for about 15 minutes before making the cake. The cake layers should still be slightly cold to the touch, which will make it easier to assemble the cake.